Neural Stem Cells And Autism

A nscs derived from dentate gyrus dg of wildtype left n 3 ptenwt m3m4 center n 4 and ptenm3m4 m3m4 right n 4 mice had similar morphology after 1 day and 5 days n.

Neural stem cells and autism.

In neural stem cells contributes to deficits in neuronal maturation. While autism is a spectrum of disorders it s clear that the more significant cases involve physical differences in the brain s nerve cells. In addition a genetic program in neural stem cells that includes several genes linked to a higher risk of developing asd turned on earlier in the cells derived from people with asd than in the cells from developmentally typical donors. No one knows why but people with autism spectrum disorder often experience a period of accelerated brain growth after birth.

A new study by ucla researchers now demonstrates how in pregnant mice inflammation a first line defense of the immune system can trigger an excessive division of neural stem cells that can cause overgrowth in the offspring s brain. As the cells grew into 3 d organoids those derived from people with asd were bigger. A recent study has suggested that therapeutic interventions such as umbilical cord blood stem cell therapy which impact immune modulation and regulation of neural connectivity have shown great promise in the treatment of autism. Neural stem cells are specified before three weeks.

Neural stem cells nscs derived from ptenm3m4 mice have higher stemness characteristics.