Neural Stem Cells Stroke

One such injury is stroke a worldwide leading cause of death and disability.

Neural stem cells stroke.

Morshead 2 5 and andras nagy1 6 1lunenfeld tanenbaum research institute mount sinai hospital toronto on m5t 3h7 canada 2donnelly centre for cellular and biomolecular. Neural stem cells nscs play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. The regenerative potential of several types of stem cells like embryonic stem cells neural stem cells adult stem cells mesenchymal stem cells and induced pluripotent stem cells have been assessed for treating stroke. Transplantation of stem cells has been proposed as a novel therapeutic strategy to promote recovery.

Cell stem cell short article adult neural stem cells from the subventricular zone give rise to reactive astrocytes in the cortex after stroke maryam faiz 1 nadia sachewsky 2 5 sergio gasco n 3 4 k w. One such injury is stroke a worldwide leading cause of death and disability. Acute ischemic stroke causes a disturbance of neuronal circuitry and disruption of the blood brain barrier that can lead to functional disabilities. A role for preconditioning and cellular engineering ischemic stroke continues to be a leading cause of morbidity and mortality throughout the world.

Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Annie bang 1 cindi m. A stem cell based stroke protocol offers great potential to restore physical functions after stroke. Many stroke patients exhibit long term disability.

Neural stem cell transplantation in ischemic stroke. This has led to major efforts to advance stem cell therapy for stroke to the clinic including our human neural stem cell hnsc product nr1 cells which is transitioning to the clinic via a california institute for regenerative medicine cirm funded disease team program. To protect and or repair the ischemic brain a multitiered approach may be centered on neural stem cell nsc transplantation. Neural stem cell transplantation can use used to replaced damaged or dead neurons and promote neurogenesis by modulating inflammation axonal plasticity remyelination angiogenesis providing neuroprotection for existing cells.

Clinical trials are ongoing but there is currently no proven stem cell based therapy for stroke. However little is known about whether these cells can form functionally integrated connections with neurons in the stroke injured recipient s brain.