P53 Mutation Cancer Cell Lines

The colon cancer p53 hotspot mutation cell panel atcc no.

P53 mutation cancer cell lines.

The hanbook of p53 mutation in cell lines. When the introduction of mutant p53 into p53 null cells was shown to give rise to a new phenotype. Tcp 2020 is composed of six select cell lines derived from colon cancer. Colorectal cancer cell lines.

175 245 248 or 273. Our laboratory has two separate culture lines of the lncap human prostate cancer cells. Atcc now offers our reliable authenticated tumor cell lines annotated with gene mutation infor mation from the sanger institute cosmic database. Analysis of p53 mutation status in human cancer cell lines.

Berglind h 1 pawitan y kato s ishioka c soussi t. Cell lines with a controversial p53 status. Cell lines by gene mutation tumor cell lines become more powerful tools for cancer research and drug discovery when the genetic abnormalities that drive their phenotype are known. The tp53 gene network in the post genomic era.

A paradigm for cell line cross contamination. Hct 116 cells contain wild type p53. Since then a large number of publications have demonstrated many gofs in numerous cell lines with a variety of p53 mutations summarized in table 1 the gof acquired by mutant p53 is further supported by the finding that patients carrying a tp53 missense mutation leading to expression of a. Knowledgebase and statistical tools for the analysis of tp53 gene mutations in human cancers.

A special issue of human mutation has been released. The p53 mutations in cell lines compendium the current version includes 2 000 and 500 cell lines with mutant tp53 and wild type tp53 respectively. Ht 29 caco 2 and sw480 contain mutated p53 were used as the panels in this study to. Esophageal cancer cell lines.

One strain lncap gw had a mutation in one of two alleles at position 273 arg. P53 gene structure and chromosome 17p alleles were studied in the three human prostate cancer cell lines lncap du 145 and pc 3. This panel combines wild type p53 cell lines with mutant p53 cell lines that carry hotspot mutations in one of the following codons. P53 mutations in cell lines.

The nci 60 panel. Epub 2008 may 11. Several fundamental features of wild type and mutant proteins and their modifications are reviewed as well as animal models and clinical aspects such as recommendations for patient care. The id cards include cell line data such as cancer type and atcc number when available as well as some specific information on potential misidentifications changes of identity or shared origins.

This special issue on tp53 propels the tp53 gene into the post genomic era. 1 karolinska institute department of oncology pathology cancer center karolinska cck stockholm. Brain cancer cell lines.